Endocrine Abstracts

One of the fundamental challenges facing current biology concerns the molecular basis for stem cell formation and behaviour. Haematopoiesis is the best characterised adult stem cell system and continues to provide paradigms of broad biological relevance. The stem cell leukaemia (SCL) gene encodes a transcription factor that is essential for the normal development of haematopoietic stem cells (HSC) and all haematopoietic lineages. Appropriate transcriptional regulation is criti...